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Recardio

Heart attack (myocardial infarction), illustration. A blocked coronary artery has led to heart muscle damage. Getty Images

Heart attack (myocardial infarction), illustration. A blocked coronary artery has led to heart muscle damage. Getty Images

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June 1, 2022 — Recardio‘s Phase 2 trial results demonstrated the excellent safety profile of its lead drug Dutogliptin along with data suggesting potential positive effects on cardiac function and were presented in May at the World Congress on Acute Heart Failure 2022 in Madrid. Along with data suggesting potential positive effects on cardiac function, it was concluded that a pivotal study of this therapeutic approach in a large, adequately powered NDA-enabling study is warranted.

After reviewing the Phase 2 trial results, the FDA agreed with the proposed trial design and sample size for the pivotal Phase 3 trial of Dutogliptin in co-adminstration with filgrastim in early recovery post-myocardial infarction. A comparable agreement was also reached with the EMA.

The global pivotal trial, named HEAL-MI, will enroll 4,000 acute myocardial infarction patients with STEMI but not specified left ventricular ejection fraction (LVEF) and with facilitated screening procedures, which will accelerate the total enrollment. The primary endpoint is a combined clinical endpoint with a Quality-of-Life evaluation as a secondary endpoint.

Based on this advice, preparations are already under way for the trial that is intended to start in the course of 2022 and will enroll patients in the key global regions – US, Europe and China.

Dr. Roman Schenk, Recardio President commented: “We appreciate the positive agency feedback and are looking forward to contributing with this HEAL-MI pivotal trial to further therapeutic options for the respective patients with myocardial infarction.”

June 1, 2022 — Recardio‘s Phase 2 trial results demonstrated the excellent safety profile of its lead drug Dutogliptin along with data suggesting potential positive effects on cardiac function and were presented in May at the World Congress on Acute Heart Failure 2022 in Madrid. Along with data suggesting potential positive effects on cardiac function, it was concluded that a pivotal study of this therapeutic approach in a large, adequately powered NDA-enabling study is warranted.

After reviewing the Phase 2 trial results, the FDA agreed with the proposed trial design and sample size for the pivotal Phase 3 trial of Dutogliptin in co-adminstration with filgrastim in early recovery post-myocardial infarction. A comparable agreement was also reached with the EMA.

The global pivotal trial, named HEAL-MI, will enroll 4,000 acute myocardial infarction patients with STEMI but not specified left ventricular ejection fraction (LVEF) and with facilitated screening procedures, which will accelerate the total enrollment. The primary endpoint is a combined clinical endpoint with a Quality-of-Life evaluation as a secondary endpoint.  

Based on this advice, preparations are already under way for the trial that is intended to start in the course of 2022 and will enroll patients in the key global regions – US, Europe and China.

Dr. Roman Schenk, Recardio President commented: “We appreciate the positive agency feedback and are looking forward to contributing with this HEAL-MI pivotal trial to further therapeutic options for the respective patients with myocardial infarction.

Are your feet swollen at night? Do your joints hurt, especially your ankles? Does it sometimes hurt to walk? It is most likely swelling. fluid enters tissues through the walls of weakened vessels, accumulates there and does not leave the body. The next stage is muscle pain and cramping, which is triggered by blood flow disorders.
Strokes and heart attacks often occur when cholesterol clogs blood vessels. Cholesterol plaques lead to the development of 90% of chronic diseases considered incurable.
Headaches, increased blood pressure, joint pain, dull pain, creaking when turning or bending the neck, bending the knees, swelling of the legs and face in the morning, ringing in the ears, cold hands and feet, impaired vision and memory, lack of energy and fatigue. Many will say that these are the faithful companions of old age. However, people at every age face similar problems.
  • Why are blood vessels responsible for 90% of your health?
  • What settles on the walls of blood vessels besides cholesterol?
  • 4 obvious and 7 hidden symptoms of unhealthy vessels
  • How to safely clean blood vessels at home?
Professor of Cardiovascular Medicine Garik Armani Sedrakyan kindly agreed to answer these and other questions.

Garik Sedrakyan performed more than 100,000 open brain surgeries in his medical practice. The youngest patient was 2 days old.
Garik Sedrakyan has the gift of explaining complex things in simple words. He wrote 47 manuals for students. The doctor is convinced that 90% of our health and well-being depend on the cleanliness of blood vessels.

Why are blood vessels responsible for 90% of our health?

Mr. Sedrakyan, you have said several times that blood vessels are responsible for 90% of the health of our body. Why?

What is the largest organ in the human body? Few people know the answer to this question. Even those who study medicine make mistakes. Some say the brain, the liver, the most intelligent say the skin. In fact, blood vessels are the largest organ.

The total length of blood vessels in the human body is 2.5 times the length of the equator.
If you remove all the vessels from the body and connect them in sequence, you will get a ribbon with a length of more than 100 thousand km.

For comparison, let’s note that the length of the equator  is 40 thousand km.

Blood vessels are not just tubes through which blood flows. It is a unique and complex organ, every deviation of which leads to disorders and chronic diseases.
Swollen, deformed blood vessels – varicose veins  accompanied by swelling, heaviness, coldness or heat in the affected limbs. Blood circulation is disturbed, the damaged parts of the body become inflamed, the risk of developing infections and ingrown nails increases.
Violation of the blood vessels feeding the liver: steatosis.  When eating oily food, a bitter taste appears in the mouth, which is the first symptom of the disease.
Fragile blood vessels of the wrists, creaking of the joints are signs of osteochondrosis.  Unpleasant pain occurs in the joints, the slightest load leads to stretching of the tendons.
Loss of elasticity of blood vessels in the intestines leads to the formation of hemorrhoids.
Violation of blood circulation in the vessels of the eye weakens vision.  A cataract develops. The eyes become inflamed, reddened, the mucous membrane dries up. This is due to microdamages of the capillaries.
Disturbance of cerebral circulation accompanied by dizziness, tinnitus and memory loss.  Have you ever walked into a kitchen and forgotten why you came? Couldn’t remember some words? These are the first symptoms of brain vessel dysfunction.

One of the most serious complications is hypertension, high blood pressure.

Blood vessels carry oxygen and nutrients throughout the body and take carbon dioxide and metabolic products from cells and tissues. If the vessels are blocked, the tissues and organs suffer from a lack of important elements. This has a negative impact on the condition of the whole organism.
“Damaged” blood vessels lead to starvation of all organs.
Excess weight  is directly related to the condition of the vessels. Cholesterol plaques narrow the lumen of blood vessels and reduce the amount of circulating blood that supplies oxygen and nutrients to tissue cells. Such a deficit awakens the hunger centers and forces us to eat. Nutrients enter the digestive system with food, but due to impaired blood circulation, the organs and tissues do not receive what they need. Thus, the process repeats endlessly.
A person experiences a constant feeling of hunger, eats a lot of fatty, sweet and high-calorie foods. As a result, weight begins to increase.
Many doctors make the mistake of claiming that hypertension is caused by excess weight. As you can see from the above explanations, excess weight is a consequence of hypertension.

Remember, the health of the body is impossible without the health of the blood vessels.”

If you want to live a healthy, full life, you need to clean and restore blood vessels.  This will save you  from 90% of chronic diseases considered incurable.

What settles on the walls of blood vessels besides cholesterol?

Everyone knows about the danger of cholesterol. It collects on the walls of blood vessels, which reduces the margin. This leads to impaired blood circulation. But this is not the only thing that accumulates in vessels.

6.1 kg –
total weight of impurities in blood vessels up to 50 years old

Cholesterol

Cholesterol plaques make up 65-70% of vascular impurities.
Up to 5 kg of cholesterol plaques accumulate  in the vessels before the age of 50  . Cholesterol blockages narrow the margin in vessels 4-5 times.

For comparison, if the diameter of the vessel is equal to the diameter of one finger, then 5 kg of cholesterol deposits narrow its margin to the diameter of 4 matches.

Cholesterol accumulation reduces the quality of life, increases blood pressure, leads to headache, abdominal pain, weakness and apathy. But this is not the worst thing, blood clots are much more dangerous.

Blood clots

The mass of blood clots, which accumulates in vessels, is much less than cholesterol –  0.8-1.0 kg  . Their main danger is instability. At any time, the blood clot can break off and start moving along the bloodstream.
This can lead to complete blockage of vessels of different diameters (depending on the size of the blood clot). As a result, the blood supply is disrupted in some parts of the body and organs.
Stroke, ischemic liver disease, lung collapse, kidney failure, hemorrhoids, gangrene – all these are the consequences of thrombosis.

Calcium salts

Calcium salts are included in the formulations of drugs and supplements. Before the age of 50 , 300-400 g of substances accumulate in the vessels of the brain . The largest amount of calcium salts accumulates in the blood vessels of the brain.
The danger of salts lies in their crystal structure. With vasospasm caused by stress, weather changes, age or physical exertion, the sharp edges of the crystal damage the vessel walls. This leads to hemorrhagic stroke.

What symptoms indicate that our blood vessels need to be cleaned? How to understand the signal sent by the body: “Urgently clean the blood vessels”.

Age older than 45 years, lack of blood purification supplements are direct indicators of blood vessel cleansing.

45
is a critical age, after which regular cleaning of vessels should be done.

Cholesterol deposits and blood clots are a result of the body’s natural aging process. Unbalanced food, bad habits, bad ecology accelerate this process 5-8 times. This is the reality we live in and we cannot deny it.

The main symptom of vascular contamination is hypertension.

If you have been diagnosed with hypertension, you may want to read no further because it is the queen of blood vessel diseases.
An increase in blood pressure is caused by a 30% or more narrowing of the margin in the vessels.
This happens because of cholesterol plaques, blood clots and calcium salt deposits. The slightest stress and weather changes affect your well-being, cause vasospasm and pressure.

4 symptoms that indicate the contamination of vessels.

  • 1. HypertensionUnstable high blood pressure that is reduced by medication.
  • 2. Varicose veinsSwelling of the veins, swelling, heaviness and pain in the affected parts of the body. Deposits accumulated on the walls of blood vessels block the normal functioning of the venous valves, leading to deformation of the walls and expansion of the vein cavity.
  • 3. HemorrhoidsVariety of varicose veins, enlargement of hemorrhoidal veins. The main symptom is rectal bleeding.
  • 4. OsteochondrosisLack of nutrition of bone and cartilage tissue, premature wear of joints, lack of synovial fluid, unpleasant pains.

7 hidden symptoms.

  • 1. SwellingIt is caused by a violation of the water-salt balance. Vessels blocked with non-elastic walls cannot remove the fluid that accumulates in tissues and organs. In the evening, the feet swell, shoes and socks leave deep marks around the toes and ankles, it becomes impossible to simply remove the ring. External swelling indicates internal, hidden swelling, which is much more dangerous for health.
  • 2. In noisy placesFrom any sound, a significant decrease in concentration. Appears as a result of increased pressure in the blood vessels of the brain.
  • 3. DizzinessEvidence of a violation of the vestibular apparatus. Often accompanied by hearing loss.
  • 4. InsomniaDrowsiness, apathy, lack of energy, fatigue. Inability to sleep is caused by malnutrition of the pituitary gland, which stops producing melatonin, the sleep hormone.
  • 5. Lack of energyLoss of strength, chronic fatigue in the morning. The reason is the lack of nutrients penetrating all tissues and organs and the narrowing of the margin in the vessels. The body goes into austerity mode to survive.
  • 6. Visual impairmentBlurring, formation of spots in front of the eyes, which indicates damage to the eye vessels.
  • 7. Pain in vesselsDifficulty moving, numbness of arms and legs, especially in the morning. It is provoked by a lack of nutrition and a change in the composition of the synovial fluid.
Have you noticed at least one of the symptoms? Your vessels need urgent cleaning.

People can often have several of these symptoms at the same time. Sometimes they can be noticed even in one person.

Often, doctors and patients treat the identified symptoms separately. Pills to reduce blood pressure, ointments for varicose veins, suppositories for hemorrhoids, diuretics for swelling, etc.
A wrong approach that will simply take money from your budget for many years. To get rid of these symptoms, it is necessary to clean the vessels.

How to free blood vessels from cholesterol, blood clots and salt deposits? order naw 

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